Best sedating anti depressant
Bridget Banas for her assistance in the preparation of this manuscript.
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This is often made worse by doctors who do not look for underlying physical problems, recommend treatments likely to make the sufferer worse — see Graded exercise and cognitive behaviour therapy (CBT) — and when the patients are worsened, they are then told they will have to "Live with it". I would also be depressed by the lack of interest, curiosity and desire to help from my physician!
This situation is often worsened by the fact that some physicians blame the patient for not engaging properly in the Graded Exercise Programme or CBT and then go on to explain that this is the reason why it hasn't worked!
The most sedating anti-depressant is trimipramine (Surmontil), dose range 10-75mgs and is the best anticholinergic where there is sleep disturbance.
Dothiepin (Prothiaden) is similar but has increased risk of cardiovascular side effects - so I never now use this.
Complicating the situation, mood stabilizers can disrupt sleep in a variety of different ways depending on a drug’s mechanism of action, dosage level, and timing of administration. The effects of trazodone on sleep in patients treated with stimulant antidepressants.
The treatment of comorbid depression and insomnia can be achieved through the use of a sedating antidepressant, a combination of two antidepressants, or a combination of an antidepressant in conjunction with a hypnotic. Psychotropic medication and priapism: a comprehensive review.
Acknowledgments: The author would like to thank Ms. 55th St, 4th Floor, New York, NY 10019; Tel: 212-994-4560; Fax: 212-523-1704; E-mail: [email protected]; Website: Nierenberg AA, Adler LA, Peselow E, Zornberg G, Rosenthal M. Mood disorders and insomnia are often comorbid conditions, sharing a complex and bi-directional relationship. Kaynak H, Kaynak D, Gozukirmizi E, Guilleminault C. I often find low doses of anticholinergics such as amitriptyline helpful, particularly in CFSs who have been poisoned by organophosphates.
Anticholinergics do not just help mood, they also improve sleep and can be effective pain relievers - it is possible that this is part of the mechanism by which these drugs help mood! Indeed I am impressed by how well psychologically adjusted many of my CFSs are!However, any chronic disease carries a risk of depression simply because sufferers lose hope of having a future.This has proven antidepressant properties and is well worth trying.